姓名：崔岩
邮箱：yan.cui@hainmc.edu.cn
教育经历：
1996/09—2001/07，北京大学医学部，基础医学，学士
2001/09—2004/07，上海中医药大学，中西医结合基础，硕士
2006/08—2007/08，香港中文大学临床肿瘤学系，肿瘤表观遗传学，博士研究生
2007/10—2012/04，德国莱布尼兹衰老研究所/耶拿大学，肿瘤细胞生物学，博士
工作经历：
2004/06—2004/12，约翰斯·霍普金斯新加坡分部，研究助理
2004/12—2006/07，香港中文大学临床肿瘤学系，研究助理
2012/05—2021/08，德国莱布尼兹衰老研究所，博士后
2021/10—至今，海南医学院，衰老与肿瘤国际研究中心
研究方向：
肿瘤信号转导与分子机理；靶向治疗
研究内容：
1. 神经纤维瘤2型基因（NF2）编码产物merlin的信号通路和分子机理研究
2. 克隆性造血的分子机理及干预策略
Name: Yan Cui
Email: yan.cui@hainmc.edu.cn
Education background:
1996/09—2001/07, Peking University Health Science Center, Basic medical science, Bachelor
2001/09—2004/07, Shanghai University of Traditional Chinese Medicine, Physiology, Master
2006/08—2007/08, Department of Clinical Oncology, the Chinese University of Hong Kong, Cancer epigenetics, PhD student
2007/10—2012/04, Leibniz Institute on Aging/Jena University, Tumor cell biology, PhD
Work experience:
2004/06—2004/12, Division of Johns Hopkins in Singapore, Research fellow
2004/12—2006/07, Department of Clinical Oncology, the Chinese University of Hong Kong, Research assistant
2012/05—2021/08, Leibniz Institute on Aging, Post-doc
2021/10—Present, International Center for Aging and Cancer, Hainan Medical University, Senior scientist
Research Area:
Cancer signaling and the molecular mechanisms; targeted therapies
Research Interests:
1. The signaling pathways and the molecular mechanisms of the tumor suppressor merlin, the neurofibromatosis type 2 (NF2) gene product
2. The molecular mechanisms underlying clonal hematopoiesis and intervention strategies
Selected publications（#first author, *Corresponding author）
1. Cui Y#*, Ma L, Schacke S, Yin JC, Hsueh YP, Jin H, Morrison H*. Merlin cooperates with neurofibromin and Spred1 to suppress the Ras-Erk pathway. Hum Mol Genet 2020; 29: 3793-3806.
2. Han S#, Cui Y*, Helbing DL. Inactivation of Horseradish Peroxidase by Acid for Sequential Chemiluminescent Western Blot. Biotechnol J 2020; 15: e1900397. Corresponding author.
3. Cui Y#*, Morrison H*. Construction of cloning-friendly minigenes for mammalian expression of full-length human NF1 isoforms. Hum Mutat 2019; 40: 187-192.
4. Cui Y#*, Groth S#, Troutman S, Carlstedt A, Sperka T, Riecken LB, Kissil JL, Jin H, Morrison H*. The NF2 tumor suppressor merlin interacts with Ras and RasGAP, which may modulate Ras signaling. Oncogene 2019; 38: 6370-6381.
5. Cui Y#, Ying Y#, van Hasselt A, Ng KM, Yu J, Zhang Q, Jin J, Liu D, Rhim JS, Rha SY, Loyo M, Chan AT, Srivastava G, Tsao GS, Sellar GC, Sung JJ, Sidransky D, Tao Q*. OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation. PLoS One 2008; 3: e2990.
