辅助生殖调控和人类辅助生殖技术方向主要相关成果

1、Yang X, Sun F, Gao Y, Li M, Liu M, Wei Y, Jie Q, Wang Y, Mei J, Mei J, Ma L, Shi Y, Chen M, Li Y, Li Q, Liu M, Ma Y. Histone acetyltransferase CSRP2BP promotes the epithelial-mesenchymal transition and metastasis of cervical cancer cells by activating N-cadherin. J Exp Clin Cancer Res. 2023 Oct 17;42(1):268. doi: 10.1186/s13046-023-02839-2. PMID: 37845756; PMCID: PMC10580587.（IF：11.3，中科院1区）

2、Xie B, Zhang L, Gao J, Wang T, Liu M, Feng X, Xu X, Ma S, Cai H, Guo T, Huang W, Tu X, Wang S, Yang H, Fang Y, Li F, Chen C. Decoding the biological properties and transcriptomic landscapes of human natural killer cells derived from bone marrow and umbilical cord blood. Am J Cancer Res. 2023 May 15;13(5):2087-2103. PMID: 37293160; PMCID: PMC10244092.（IF:4.7,中科院3区）

3、Jin YB, Liang XC, Cai JH, Wang K, Wang CY, Wang WH, Chen XL, Bao S. Mechanism of action of icaritin on uterine corpus endometrial carcinoma based on network pharmacology and experimental evaluation. Front Oncol. 2023 Jul 19;13:1205604. doi: 10.3389/fonc.2023.120560. PMID: 37538114; PMCID: PMC10394632.（IF:5.3,中科院3区）

4、Qiuling Jie, Lijun Chen, Jiangying Liang, Xiaohui Yang, Fei Sun, Yanlin Ma. Downregulated ETV4 inhibits the proliferation, migration and invasion of trophoblast cells in preeclampsia. Reproduction. 2023 Mar 8;165(4):373-381.（IF=3.8，3区）

5、Jiaxing Wang, Ping Long, Shengnan Tian, Weihua Zu, Jing Liu, Bangyong Wu, Jilong Mao, Dan Li, Yanlin Ma, and Yuanhua Huang. Cyclosporin A promotes invasion and migration of extravillous trophoblast cells derived from human induced pluripotent stem cells and human embryonic stem cells.Stem Cells and Development. 2023 Feb;32(3-4):60-74. （IF=4.0，3区）

6、Fei Sun, Yunjian Wei, Zheng Liu, Qiuling Jie, Xiaohui Yang, Ping Long, Jun Wang, Ying Xiong, Qi Li, Song Quan, Yanlin Ma.Acylglycerol kinase promotes ovarian cancer progression and regulates mitochondria function by interacting with ribosomal protein L39. J Exp Clin Cancer Res. 2022 Aug 8;41(1):238.（IF=12.658，1区）

7、Fei Sun ,Qiuling Jie，Qi Li ,Yunjian Wei ,Hong Li，Xiaojing Yue ,Yanlin Ma.TUSC3 inhibits cell proliferation and invasion in cervical squamous cell carcinoma via suppression of the AKT signalling pathway. J Cell Mol Med.2022 Mar;26(5):1629-1642. （IF: 5.31，2区，）

8、Hui Lu, Dongchuan Xu, Ping Wang, Wenye Sun, Xinhuai Xue, Yuxin Hu, Chunli Xie, Yanlin Ma. RNA-Sequencing and Bioinformatics Analysis of Long Noncoding RNAs and mRNAs in the asthenozoospermia[J]. Bioence Reports, 2020, 40(7).（IF: 2.942）

9、Ke Huang, Yanling Zhu, Yanlin Ma , et al. BMI1 enables interspecies chimerism with human pluripotent stem cells. Nature communications, 2018, 9(1): 4649. （SCI收录，IF: 12.353）

10、Yanxing Wei, Xiaohua Zhou, Wenhao Huang , et al. Generation of trophoblast-like cells from the amnion in vitro: A novel cellular model for trophoblast development. PLACENTA. 2017 Mar;51:28-37.（SCI 妇产科学 2 区，IF=2.434）

11、Xiaojing Yue, Ying Sun, Mei Zhong , et al. Decreased expression of fibroblast growth factor 13 in early-onset preeclampsia is associated with the increased trophoblast permeability[J]. Placenta, 2018, 62: 43-49. （SCI 妇产科学 2 区, IF=2.434）

12、Zhi Zhou*, Yan-Lin Ma, Qi Li , et al. Clinical application of oligo array-CGH for detecting balanced translocations in preimplantation genetic diagnosis. Int J Clin Exp Pathol, 2017;10(7): 7821-7835.（IF=1.396）

13、Grace Wing Shan Kong, Yanlin Ma, Jian Ou , et al. Validation of a High-throughput and Robust Technique: BACs-on-Beads Assay (KaryoLiteBoBs) for Pre-implantation Aneuploidy Screening. Taiwan Association of Obstetrics and Gynecology. 2017 Jan 27.（IF= 1.029）

14、Xie BG, Lu WY, Huang YH, et al. Quality of life in cervical cancer treated with systematic nerve-sparing and modified radical hysterectomies [J]. J ObstetGynaecol, 2015, 35(8): 839-843.（IF=0.629）

15、Xie BG, Huang YH, Zhu WJ, et al. Comparison of the outcome of conventional in vitro fertilization andintracytoplasmic sperm injection in moderate male infertility from ejaculate [J]. Urol Int, 2015, 94(1):111-116. （IF=1.611）

16、石敏洁,谢宝国.子宫内膜癌分子分型检测的研究进展[J].中国医药导报,2023,20(01):65-67+89.DOI:10.20047/j.issn1673-7210.2023.01.14

17、刘萍,黄健,谢宝国.血红素加氧酶-1基因转染骨髓间充质干细胞移植对化疗所致卵巢早衰的保护作用[J].中国临床药理学杂志,2023,39(05):679-683.DOI:10.13699/j.cnki.1001-6821.2023.05.015

18、韩众益,吴婷婷,马燕琳.探讨GnRH拮抗剂方案的标准剂量及早发LH峰后的剂量调整[J/OL].海南医学院学报,1-12[2024-01-04]https://doi.org/10.13210/j.cnki.jhmu.20230515.003

19、周虹雨,谢宝国,吴亚妹等.生长激素添加对高龄卵巢储备功能减退患者IVF-ET妊娠结局的疗效研究[J].中国生育健康杂志,2023,34(03):234-238.

20、林建丽,李慧,吴小妹等.复发性流产血栓前状态孕妇血清BNP、ATⅢ、Anti-β2-GPI水平对疾病转归的预测价值[J].广东医学,2023,44(05):596-601.DOI:10.13820/j.cnki.gdyx.20224865

21、王亚妹,谢宝国.多囊卵巢综合征患者外周血单核细胞TLR4表达及其与胰岛素抵抗指数的相关性[J].山东医药,2023,63(21):68-70.

22、吴婷婷,江欣星,马燕琳.雌激素预处理在拮抗剂方案中的作用-Meta分析[J].海南医学院学报,2023,29(17):1332-1338+1345.DOI:10.13210/j.cnki.jhmu.20230331.001

23、李蒙勇威,康金雨,林丹等.TUSC3在子痫前期胎盘组织中的表达及对滋养细胞功能的影响[J].海南医学院学报,2023,29(18):1389-1394+1400.DOI:10.13210/j.cnki.jhmu.20230616.001

24、梅娇琪,杨晓惠,李蒙勇威等.ICOSL/ICOS在母胎免疫耐受中的研究进展[J].海南医学院学报,2023,29(23):1831-1835.DOI:10.13210/j.cnki.jhmu.20221229.001

人胚的发育与分化和干细胞治疗领域主要相关成果

1、Zhuo Ma, Xiaofei Zhang, Wen Zhong, Hongyan Yi, Xiaowei Chen, Yinsuo Zhao, Yanlin Ma, Eli Song, Tao Xu. Deciphering early human pancreas development at the single-cell level. Nature Communication. 2023 Sep 2;14(1):5354.（IF=16.6，1区）

2、Shangtao Cao, Huijian Feng, Hongyan Yi, Mengjie Pan, Lihui Lin, Yao Santo Zhang, Ziyu Feng, Weifang Liang, Baomei Cai, Qi Li, Zhi Xiong, Qingmei Shen, Minjing Ke, Xing Zhao, Huilin Chen, Qina He, Mingwei Min, Quanyou Cai, He Liu, Jie Wang, Duanqing Pei, Jiekai Chen, Yanlin Ma. Single-cell RNA sequencing reveals the developmental program underlying proximal-distal patterning of the human lung at the embryonic stage. Cell Research. 2023 Apr 21. doi: 10.1038/s41422-023-00802-6. （IF=44.1，1区）

3、Wang J, Ma L, Mei J, Li L, Xu W, Jiang W, Wei Y, Xu Y, Sun S, Ma Y, Li Q. Impacts of different culture times on pregnancy outcomes after thawing of cleavage stage embryos. BMC Pregnancy Childbirth. 2023 Nov 29;23(1):824. doi: 10.1186/s12884-023-06139-7. PMID: 38031033; PMCID: PMC10685551.（IF：3.1，中科院2区）

4、Yang X, Sun F, Gao Y, Li M, Liu M, Wei Y, Jie Q, Wang Y, Mei J, Mei J, Ma L, Shi Y, Chen M, Li Y, Li Q, Liu M, Ma Y. Histone acetyltransferase CSRP2BP promotes the epithelial-mesenchymal transition and metastasis of cervical cancer cells by activating N-cadherin. J Exp Clin Cancer Res. 2023 Oct 17;42(1):268. doi: 10.1186/s13046-023-02839-2. PMID: 37845756; PMCID: PMC10580587.（IF：11.3，中科院1区）

5、Xie B, Zhang L, Gao J, Wang T, Liu M, Feng X, Xu X, Ma S, Cai H, Guo T, Huang W, Tu X, Wang S, Yang H, Fang Y, Li F, Chen C. Decoding the biological properties and transcriptomic landscapes of human natural killer cells derived from bone marrow and umbilical cord blood. Am J Cancer Res. 2023 May 15;13(5):2087-2103. PMID: 37293160; PMCID: PMC10244092.（IF:4.7,中科院3区）

6、Jin YB, Liang XC, Cai JH, Wang K, Wang CY, Wang WH, Chen XL, Bao S. Mechanism of action of icaritin on uterine corpus endometrial carcinoma based on network pharmacology and experimental evaluation. Front Oncol. 2023 Jul 19;13:1205604. doi: 10.3389/fonc.2023.120560. PMID: 37538114; PMCID: PMC10394632.（IF:5.3,中科院3区）

7、Qiuling Jie, Lijun Chen, Jiangying Liang, Xiaohui Yang, Fei Sun, Yanlin Ma. Downregulated ETV4 inhibits the proliferation, migration and invasion of trophoblast cells in preeclampsia. Reproduction. 2023 Mar 8;165(4):373-381.（IF=3.8，3区）

8、Jiaxing Wang, Ping Long, Shengnan Tian, Weihua Zu, Jing Liu, Bangyong Wu, Jilong Mao, Dan Li, Yanlin Ma, and Yuanhua Huang. Cyclosporin A promotes invasion and migration of extravillous trophoblast cells derived from human induced pluripotent stem cells and human embryonic stem cells.Stem Cells and Development. 2023 Feb;32(3-4):60-74. （IF=4.0，3区）

9、Ping Long, Yuechuan Shi, Fei Sun, Yunjian Wei, Bangyong Wu, Qi Li, Qiuling Jie,Yanlin Ma.Establishment of a non‐integrated induced pluripotent stem cell line derived from human chorionic villi cells. J Clin Lab Anal, 2022: e24464.9.（IF: 3.124，3区）

10、Lingli Li , Hongyan Yi , Zheng Liu, Ping Long , Tao Pan Yuanhua Huang , Yongsheng Li , Qi Li , Yanlin Ma.Genetic correction of concurrent α- and β-thalassemia patient-derived pluripotent stem cells by the CRISPR-Cas9 technology. Stem Cell Res Ther. 2022 Mar 7;13(1):102.（IF: 6.832，2区）

11、Zuxia Mi,Zheng Liu,Yu Zhang,Juan Zhu, Yufei Yao,Yao Zhou,Yuanhua Huang,Qi Li,Yanlin Ma.Number of Blastomeres in Day-2 Embryos Affect the Rates of Blastocyst Formation and Clinical Pregnancy During In Vitro Fertilization Cycles.Reproductive Sciences.2021 Dec;28(12):3397-3405.

12、Liren Wang, Linxi Li, Yanlin Ma, Handan Hu, Qi Li, Yang Yang, Wenbang Liu,Shuming Yin, Wei Li, Bin Fu, Ryo Kurita,Yukio Nakamura, Mingyao Liu, YongrongLai, and Dali Li. Reactivation of γ-globin Expression through Cas9 or Base Editor to Treat β-Hemoglobinopathies[J]. Cell research. 2020, 30(3): 276-278.（IF: 20.507）

13、Ping Long, Zheng Liu, Bangyong Wu, Jingxi Chen, Chao Sun, Fei Wang, Yuanhua Huang, Hongjian Chen, Qi Li, Yanlin Ma. Generation of an induced pluripotent stem cell line from chorionic villi of a Patau syndrome spontaneous abortion[J]. Stem Cell Research, 2020, 45:101789. （IF: 4.489）

14、Ping Long, Zhen Wang, Huamei Yang, Zheng Liu, Bangyong Wu, Gaobu Zhong, Jingxi Chen, Chao Sun, Fei Wang, Yao Zhou, Fei Sun, Qi Li, Yanlin Ma. Generation of nine iPSC lines (HNMUi002-A, HNMUi003-A, HNMUi004-A, HNMUi005-A, HNMUi006-A, HNMUi007-A, HNMUi008-A, HNMUi009-A, HNMUi010-A) from three Chinese families with thalassemia[J]. Stem Cell Research, 2020, 45:101821. （IF: 4.489）

15、Yu Zhang, Hongyan Liu， Zheng Liu, Ping Long, Xing Zhao, Qi Li, Yuanhua Huang, Yanlin Ma. Cryopreservation of human induced pluripotent stem cells by using a new CryoLogic vitrification method[J].Cryobiology, https://doi.org/10.1016/j.cryobiol.2020.10.019（IF: 2.283）

16、Yanlin Ma*, Qi Li, Ankang Li, et al. The CSRP2BP histone acetyltransferase drives smooth muscle gene expression. Nucleic Acids Res. 2017 Apr 7; 45(6):3046-3058.（IF: 11.561，第一，共同通讯）

17、Yanlin Ma, Jun Wang, Robert J. Schwartz*. PKG-1α mediates GATA4 transcriptional activity. Cellular Signalling. 2016 Jun;28(6):585-94.（IF:3.478）

18、Rasmussen TL, Ma Y, Park CY , et al. Smyd1 Facilitates Heart Development by Antagonizing Oxidative and ER Stress Responses. PLoS One. 2015 Mar 24;10(3):e0121765. （IF: 2.776，共同第一作者）

19、Zhenqiang Zhao, Yanlin Ma, Zhibin Chen , et al. Effects of Feeder Cells on Dopaminergic Differentiation of Human Embryonic Stem Cells. Front Cell Neurosci, 2016 Dec 20;10:291. （IF: 4.300，共同第一）

20、Xing Zhao, Qi Li, Wei-Min Jiang, et al. Expression level of pluripotent genes in incomplete reprogrammin. Asian Pacific Journal of Tropical Medicine. 2014, 7(8): 639-644.（IF: 1.634，共同通讯作者)

21、Hengxiang Cui, Yeqi Wang, Huizhe Huang, et al. GPR126 Regulates Developmental and Pathological Angiogenesis through Modulation of VEGFR2 Signaling. Journal of Chemical Biology, 2014, 289(50): 34871-34885.（IF: 4.010，共同通讯作者)

22、王明昆,黄元华,马燕琳.育龄期女性体重指数对胚胎发育及助孕结局的影响[J].海南医学院学报,2023,29(24):1870-1877.

遗传疾病的诊断、产前诊断和治疗研究方向主要相关成果

1、李丹,马燕琳,揭秋玲,邓毅,孙海华,朱定红.师生互动平台在医学专业英语教学改革与创新人才培养中的应用[J].创新创业理论研究与实践,2020,3(17):33-36.

2、谢春丽,卢惠,张凌霄,赵星,沈家慧,马燕琳.左卡尼汀单药治疗男性不育症有效性的Meta分析[J].中国药房,2020(15). （通讯作者）

3、徐秋霞,马燕琳.环孢素A调节自噬对人滋养细胞氧化应激损伤的影响[J].实用药物与临床,2020(05). （通讯作者）

4、揭秋玲,李崎,孙文页,周繇,陈宏健,黄慧敏,卢伟英,马燕琳.海南地区地中海贫血筛检者的基因结果分析[J].实用医学杂志,2020(08). （通讯作者）

5、陈竞茜, 揭秋玲, 龙平, 钟高布, 孙超, 卢惠, 王樱瑾, 王军, 马燕琳. 不同产前诊断指征的羊水细胞染色体核型分析[J]. 实用医学杂志, 2019, 35(23):3656-3661（通讯作者）

6、卢惠, 黎明红, 薛欣怀, 王关辉, 云天英, 马燕琳. 一例由母源18号染色体倒位引发的18q部分三体综合征患儿的产前遗传学诊断与分析[J]. 海南医学院学报, 2019, 25(20):1585-1588.（通讯作者）

7、张毅, 陈松, 陈宏健, 卢惠, 周繇, 马燕琳. 双酚 A 对人早孕绒毛滋养细胞 IGF-I 及 ADAM12 表达的影响[J]. 中国临床研究, 2019, 32(7): 893-897. （通讯作者）

8、李崎，马燕琳等；引物组及试剂盒；国家发明专利；2018年1月受理；专利受理号: 201810064134.8

9、李崎，马燕琳等；引物组及试剂盒；国家发明专利；2018年1月受理；专利受理号: 201810062884.1

10、冯涛，李崎，马燕琳等； Y 染色体AZF 区微缺失检测试剂盒；国家发明专利；2015 年10 月受理；专利受理号: 201510680779.0

11、马燕琳，李崎等；HBB 基因突变和HLA 分型检测试剂盒；国家发明专利；2015 年12 月受理；专利受理号: 201510900715.7

12、Fang X, Gong Y, Ma Y, Huang Y. Application of next-generation sequencing in thalassemia screening: A systematic review and meta-analysis. Asian Pacific Journal of Tropical Medicine 2023; 16(2): 51-57（IF=3.1，4区）

13、Zhou W, Jie Q, Pan T, Shi J, Jiang T, Zhang Y, Ding N, Xu J, Ma Y, Li Y. Single-cell RNA binding protein regulatory network analyses reveal oncogenic HNRNPK-MYC signalling pathway in cancer. Commun Biol. 2023 Jan 21;6(1):82. doi: 10.1038/s42003-023-04457-2。（IF：5.9，中科院1区）

14、Haozhe Zou, Tao Pan, Yueying Gao, Renwei Chen, Si Li, Jing Guo, Zhanyu Tian, Gang Xu, Juan Xu, Yanlin Ma, Yongsheng Li.Pan-cancer assessment of mutational landscape in intrinsically disordered hotspots reveals potential driver genes. Nucleic Acids Res. 2022 Jan 21:gkac028.（IF: 16.971，1区）

15、Yao Zhou, Xiaohui Yang, Zheng Liu, Yu Zhang, Huaye Chen, Yongfang Zhang, Yuxin Hu, Yanlin Ma, Qi Li. Excluding embryos with two novel mutations in FREM2 gene by the next-generation sequencing-based single nucleotide polymorphism haplotyping. Aging (Albany NY). 2021,13(22):24786-24794. （IF: 5.682，2区）

16、Sun F, Jie Q, Li Q, Wei Y, Li H, Yue X, Ma Y. TUSC3 inhibits cell proliferation and invasion in cervical squamous cell carcinoma via suppression of the AKT signalling pathway. J Cell Mol Med. 2022 Mar;26(5):1629-1642. （IF: 5.31，2区）

17、Zhen Wang, Wenye Sun, Huaye Chen, Yongfang Zhang, Fei Wang, Hongjian Chen, Yao Zhou, Yanhua Huang, XiXi Zhou, Qi Li.,Yanlin Ma. Prevalence and molecular spectrum of α‑andβ‑globin gene mutations in Hainan, China.International Journal of Hematology.2021,Jun 30. doi: 10.1007/s12185-021-03173-z.(IF:2.490)

18、Zhen Wang, Robert J Schwartz, Jing Liu, Fei Sun, Qi Li, Yanlin Ma. Smyd1 Orchestrates Early Heart Development through Positive and Negative Gene Regulation. Front. Cell Dev. Biol., 2021, 9:654682.（IF: 5.186）

19、 Qiuling Jie, Fei Sun, Qi Li, Juan Zhu, Yunjian Wei, Huamei Yang, Ping Long, Zhen Wang, Xiaohui Yang, Dan Li, Liping Huang, Yanlin Ma. Downregulated ribosomal protein L39 inhibits trophoblast cell migration and invasion by targeting E-cadherin in the placenta of patients with preeclampsia. FASEB J. 35(4):e21322.（IF: 4.966）

20、Chao Liang, Xue-yin Chen, Xue Gao, Hong-jian Chen, Ying-xia Jin, Yao Zhou, Ming-hong Li, Wen-cong Wang, Wei-ying Lu, Yuan-hua Huang, Jun Wang, Qi Li,Yan-lin Ma. Spectrum of thalassemia mutations in fetuses of Han and Li people in Hainan province of China. Asian Pacific Journal of Tropical Medicine, 2019; 12(12): 537-544（IF: 1.772）

21、Juan Zhu, Yunjian Wei, Zhen Wang, Qiuling Jie, Fei Sun, Qi Li, Ping Long, Yuanhua Huang, Yanhong Yu, Yanlin Ma. Down-regulated FOXA1 in early-onset pre-eclampsia induces apoptosis, and inhibits migration and invasion of trophoblast cells[J]. J Gene Med. 2020, 7:e3273.（IF: 3.258）

22、Yu Zhang, Zheng Liu, Jian Ou, Ling-Xiao Zhang, Wei-Ying Lu, Qi Li, Yanlin Ma. Successful surgical sperm retrieval from a patient with 45,X/46,XY mosaicism followed by in vitro fertilization pregnancy A case report. Medicine (Baltimore)[J]. 2020, 99(40):e22223.（IF: 1.552）

23、Wei Huang, Weiying Lu, Qi Li, Yu Zhang, Baoguo Xie, Shu Luo, Yunjian Wei, Yanlin Ma and Yuanhua Huang. Effects of cyclosporine A on proliferation, invasion and migration of HTR-8/SVneo human extravillous trophoblasts[J]. Biochemical and Biophysical Research Communications. 2020（IF: 2.985）

24、 Yuting Guan, Yanlin Ma, Qi Li, et al. CRISPR/Cas9-mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse. EMBO Mol Med. 2016 May 2;8(5):477-88. （IF: 10.239）

25、Liren Wang, Yanjiao Shao, Yuting Guan , et al. Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos[J]. Scientific reports. 2015, 5 :17517. (SCI 收录, IF: 4.122)

26、Fei Sun, Lu Xiao, Xin-Xing Jang , et al. TRPV6 is a prognostic marker in early-stage cervical squamous cell carcinoma. Tumor Biology, 2016, 37(12): 15743-15751.（IF: 2.926）

27、Fei Sun, Ying Xiong, Xiao-Hua Zhou , et al. Acylglycerol kinase is over-expressed in early-stage cervical squamous cell cancer and predicts poor prognosis. Tumor Biology, 2016, 37(5):6729-6736.（IF: 2.926）