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张小坡教授

发布时间:2019-12-02 16:00:22 发布人: 作者: 编辑:药学院 来源: 浏览次数:

张小坡,1982年生,博士(博士后),教授,药学院副院长,海南省“515”三层次人才。2010年毕业于沈阳药科大学,获药学博士学位;2014年于北京协和医学院博士后流动站出站(药学专业)。研究领域为天然药物化学,研究方向为南药黎药活性成分的提取分离、结构测定、结构修饰、药效评价和作用机制研究,并在此基础上开展新药研发工作。主持国家自然科学基金3项(结题1项,在研2项)、中国博士后面上项目1项(已结题)。以第一或通讯作者在Scientific Reports, Journal of Natural Products, Records of Natural Products, PlosOne, Journal of Nutritional Biochemistry, Fitotoerapia, Phytochemistry Letters, Chem Phram Bull, Nat Prod ResSCI源刊收录的期刊上发表论文近30篇。参与撰写专著3部,授权专利1项。

主持的课题:

[1] 潺槁木阿朴菲生物碱类PTP1B抑制剂的发现及其改善胰岛素抵抗作用机制研究,国家自然科学基金地区基金,20181-202112月。

[2] 黎药-葫芦茶中新颖苯丙素苷类Nrf2激活剂的发现及其糖尿病肾病保护机制研究,81560696,国家自然科学基金地区基金,20161-201912月。

[3]基于AMPK激活作用的黎药-野菠萝双四氢呋喃型木脂素降脂活性成分及其构效关系研究,81202994,国家自然科学基金青年基金,20131-201512月。

主编的专著:

[1]高良姜现代研究》,北京:科学出版社,2015.12本人主编。

[2]制药工程技术及进展研究》,吉林:吉林大学出版社,2015.4,本人主编。

荣获的奖励:

《融合南药黎药特色的药学人才培养模式探索与实践》,海南省教学成果一等奖,2017年,排名第5

发表的SCI论文:

[1] Xiaopo Zhang, Yan Jin, Younan Wu, Caiyun Zhang, Dejun Jin, Qingxia Zheng, Youbin Li. Anti-hyperglycemic and anti-hyperlipidemia effects of the alkaloid-rich extract from barks of Litsea glutinosa in ob/ob mice. Sci Rep. 2018, 8(1): 12646.

[2] Shuai Wang, Chongming Wu, Li X,Yue Zhou, Zhang Q, Ma F, Wei J, Xiaopo Zhang*, Peng Guo*. Syringaresinol-4-O-β-d-glucoside alters lipid and glucose metabolism in HepG2 cells and C2C12 myotubes. Acta Pharm Sin B. 2017, 7(4):453-460.

[3] Wang S#, Zhang X#, Li X, Liu Q, Zhou Y, Guo P, Dong Z, Wu C. Phenylpropanoid glucosides from Tadehagi triquetrum inhibit oxLDL-evoked foam cell formation through modulating cholesterol homeostasis in RAW264.7 macrophages. Nat Prod Res. 2017, 4:1-4.

[4] Yu L, Jiang B, Chen Z, Wang X, Shang D, Zhang X*, Sun Y, Yang J, Ji Y. Cytisine induces endoplasmic reticulum stress caused by calcium overload in HepG2 cells. Oncol Rep. 2018, 39(3):1475-1484.

[5] Yixin Qian, Jichuan Kang*, Yikai Luo, Jun He, Lu Wang, Xiaopo Zhang*. Secondary metabolites of an endophytic fungus pestalotiopsis uvicola[J]. Chemistry of Natural Compounds, 2017, 53(4): 756-757.

[6] Younan Wu, Yan Jin, Lin Dong, Yiying Li, Caiyun Zhang, Mei Gui*, Xiaopo Zhang*. New lignan glycosides from the root barks of Litsea glutinosa[J]. Phytochemistry Letters, 2017, 20: 259-262.

[7] Lin Na, Bo Yi, Juan Li, Wanke Zhang*, Xiaopo Zhang*. A new sugar ester from the roots of Acanthus ilicifolius[J]. Records of Natural Products, 2017, 11(1):74-76.

[8] Xiaopo Zhang, Mei Gui, Caiyun Zhang, Changyu Chen, Lei Yu*, Jie Liu*. Leucasinoside: A new abietane diterpenoid glycoside from Leucas zeylanica[J]. Records of Natural Products, 2017, 11(1):74-76.

[9] Yinfeng Tan, Ni An, Yonghui Li, Shouqian Chen, Junqing Zhang, Xiaopo Zhang*, Youbin Li*. Two new isoflavonoid glucosides from the roots of Achyranthes bidentata and their activities against nitric oxide production[J]. Phytochemistry Letters, 2016, 17:187-189.

[10] Xiaopo Zhang, Changyu Chen, Yonghui Li, Deli Chen, Lin Dong, Na Wei, Chongming Wu, Junqing Zhang, Youbin Li. Tadehaginosides A-J, phenylpropanoid glucosides from Tadehagi triquetrum, enhance glucose uptake via the upregulation of PPARγ and GLUT-4 in C2C12 myotubes[J]. Journal of Natural Products, 2016, 79(5): 1249-1258.

[11] Dan Zhao, Lijun Xie, Lei Yu, Ni An, Na Wei, Fen Chen, Youbin Li, Yinfeng Tan*, Xiaopo Zhang*. 2-Benzoxazolinone derivatives with cytotoxic activities from the roots of Acanthus ilicifolius[J]. Chemical & Pharmaceutical Bulletin, 2015, 63(12):1087-1090.

[12] Guoxu Ma#, Xiaopo Zhang#, Pengfei Li, Zhonghao Sun, Nailiang Zhu, Yindi Zhu, Junshan Yang, Deli Chen, Haifeng Wu, Xudong Xu. Four new phenolic acid with unusual bicycle [2.2.2] octane moiety from Clerodendranthus spicatus and their anti-inflammatory activity[J]. Fitoterapia, 2015, 105: 61-65.

[13] Tingting Zhang, Caiyun Zhang, Weiwei Guan, Dan Zhao, Ni An, Feng Chen, Bei Li*, Xiaopo Zhang*. New phenylpropanoids with cytotoxic activities from Drypetes hainanensis[J]. Phytochemistry Letters, 2015, 12: 186-189.

[14] Xiaopo Zhang, Shuai Wang, Yonghui Li, Dan Zhao, Ni An, Jiani Wu, Tingting Zhang, Chongming Wu, Youbin Li. Tadehaginoside modulates lipogenesis and glucose consumption in HepG2 cells[J]. Natural Product Research, 2015, 29(24): 2287-2290.

[15] Jiani Wu, Caiyun Zhang, Tingting Zhang, Dan Zhao, Ni An, Youbin Li, Nailiang Zhu, Shuai Wang, Feng Chen*, Xiaopo Zhang*. A new lignan with hypoglycemic activity from Tadehagi triquetrum[J]. Natural Product Research, 2015, 29(18): 1723-1727.

[16] ChongmingWu#, Xiaopo Zhang#, Xue Zhang, Hong Luan, Guibo Sun, Xiaoliang Wang, Peng Guo, Xudong Xu. The caffeoylquinic acid-rich Pandanus tectorius fruit extract increases insulin sensitivity and regulates hepatic glucose and lipid metabolism in diabetic db/db mice[J].  Journal of Nutritional Biochemistry, 2014, 25, 412-419.

[17] Xiaopo Zhang, Yinfeng Tan, Yonghui Li, Lifeng Jin, Na Wei, Haifeng Wu, Guoxu Ma, Qingxia Zheng, Yu Tian, Junshan Yang, Junqing Zhang, Xudong Xu. Aphanamixins A-F, acyclic diterpenoids from the stem bark of Aphanamixis polystachya[J]. Chem. Pharm. Bull., 2014, 62(5): 494-498.

[18] Feng Chen,  Hailong Li,  Yin-Feng Tan,  Weiyong Lai,  Zhenmiao Qin,  Hongdie Cai,  Yonghui Li,  Junqing Zhang*, Xiaopo Zhang*.  A sensitive and cost-effective LC–ESI–MS/MS method for quantitation of euscaphic acid in rat plasma using optimized formic acid concentration in mobile phase[J]. Analytical Methods, 2015, 21(7): 2155-2160.

[19] Xiaopo Zhang, Chongming Wu, Haifeng Wu, Linghui Sheng, Yan Su, Xue Zhang, Hong Luan, Guibo Sun, Yu Tian, Yubin Ji, Peng Guo, Xudong Xu. Anti-hyperlipidemic effects and potential mechanisms of action of the caffeoylquinic acid-rich Pandanus tectorius fruit extract in hamsters fed a high fat-diet[J]. PlosOne, 2013, 8(4): e61922.

[20] Xiaopo Zhang, Haifeng Wu, Chongming Wu, Peng Guo, Xudong Xu, Meihua Yang. Pandanusphenol A and B: two new phenolic compounds from the fruits of Pandanus tectorius Soland[J]. Records of Natural Products, 2013, 7(4):359–362.

[21] Haifeng Wu, Xiaopo Zhang, Ying Wang, Jing-Yi Zhang, Guoxu M, Yu Tiana, Lizhen Wu, Shi-Lin Chen, Junshan Yang, Xudong Xu. Four new diterpenes from Aphanamixis polystachya[J]. Fitoterapia, 2013, 90, 126-131.

[22] Xiaopo Zhang, Caiyun Zhang, Guangli Sun, Xudong Xu, Yinfeng Tan, Haifeng Wu, Rennan Cao, Jing Liu, Jianwei Wu. Cyclodextrins and their derivatives in the resolution of chiral natural products: a review[J]. Instrumentation Science & Technology, 2012, 40(2-3): 194-215.

[23] Xiaopo Zhang, Junqing Zhang, Yinfeng Tan, Qibing Liu, Mingsheng Liu. Deoxycalyciphylline B, a hepatotoxic alkaloid from Daphniphyllum calycinum[J]. Molecules, 2012, 17(8): 9641-9651.

[24] Xiaopo Zhang, Na Wei, Jian, Huang, Yinfeng Tan, Dejun Jin. A new feruloyl amide derivative from the fruits of Tribulus terrestris[J]. Natural Product Research, 2012, 26(2): 1922-1925.

 
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